National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m20304

Testing Status of Ethyl methanesulfonate - M20304

 

CASRN: 62-50-0

Formula: C3-H8-O3-S

Synonyms/Common Names

  • Methanesulphonic acid ethyl ester (9CI)

Known Uses

Biochemical research, possible contraceptive

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • C. elegans  (S0950)  Completed 
    • C. elegans

Genetic Toxicology

  • Chromosome Aberrations  (998123)  Completed 
    • Mice
    •  Positive (Nonstandard Protocol) 
  • Comet Assay  (G20304B)  Completed 
    • Rats
  • In Vitro Cytogenetics (CA/SCE)  (975642)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • (F25967)  On Test 
    • (F97876)  On Test 
      • Micronucleus  (A45799)  Completed 
        • Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
        • Rats: Fischer 344
        • Male Positive 
        • Female NA 
      • Micronucleus  (A84681)  Completed 
        • Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
        • Mice: B6C3F1
        • Male Positive 
        • Female Negative 
      • Micronucleus  (F45799)  Completed 
        • Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
        • Rats: Fischer 344
        • Male Positive 
        • Female NA 
      • Micronucleus  (F84681)  Completed 
        • Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
        • Mice: B6C3F1
        • Male Positive 
        • Female NA 
      • Micronucleus  (G20304)  Completed 
        • Rats: Wistar Han
        • Male Positive 
      • Salmonella  (764747)  Completed 
        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
        • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
        •  Positive 
      • Salmonella  (N-9142)  Completed 
        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
        • Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251

      Organ Systems Toxicity

      • Preimplantation Zygote Effects (Intravenous)  (PZEF53)  Completed 
        • Citation: Generoso, W.M., Rutledge, J.C., Cain, K.T., Hughes, L.A., and Downing, D.J. Mutagen-induced fetal anomalies and death following treatment of females within hours after mating. Mutation Res. 199: 175-181 (1988).
        • Female Mice: C3H X C57BL
        • Mice Female Positive 
      NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.