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Testing Status of Pentaerythritol triacrylate M20309

 

CASRN: 3524-68-3

Formula: C14-H18-O7

Synonyms/Common Names

  • PETA
  • 2-Propenoic acid, 2-(hydroxymethyl)-2-(((1-oxo-2-propenyl)oxy)methyl)-1,3-propanedi-yl ester (9CI)

Known Uses

Radiation curing of urethanes, epoxy resins, polyether resins, acrylic acid derivative (HSDB 1990)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C88127)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 2.5, 25, 50, 100, OR 200 MG/KG.
  • 26 weeks (Topical Application)  (C88127B)  Completed 
    • GMM-04 (NIH Number: 06-4451)  (Peer Review Approval 09/06/2002A )
      Toxicology Studies of Pentaerythritol Triacrylate (Technical Grade) (CASRN 3524-68-3) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 0.75, 1.5, 3, 6, OR 12 MG/KG; 15/SEX/DOSE.
  • 13 weeks (Topical Application)  (C88127)  Completed 
    • GMM-04 (NIH Number: 06-4451)  (Peer Review Approval 09/06/2002A )
      Toxicology Studies of Pentaerythritol Triacrylate (Technical Grade) (CASRN 3524-68-3) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.75, 1.5, 3, 6, OR 12 MG/KG; 10/SEX/SPECIES/GROUP.

Genetic Toxicology

  • Micronucleus  (A28145)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A76067)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Equivocal 
    • Female Positive 
  • Salmonella  (636180)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • varies Immunotoxicity (Topical Application)  (IMM95011)  Completed 
    • Female Mice: BALB/c
    • Dose: 0.01, 0.05 AND 0.10% FOR SENSITIZATION, AND 0.25% FOR CHALLENGE IN THE MEST AND 0.05, 0.10, AND 0.25% FOR SENSITIZATION IN THE LLNA. DNFB (2, 4-DINITROFLUOROBENZENE) USED AS POSITIVE CONTROL AT 0.20% FOR SENSITIZATION AND 0.20 FOR CHALLENGE.
  • varies Immunotoxicity (Topical Application)  (IMM97005)  Completed 
    • Female Mice: BALB/c
    • Dose: 0.01, 0.05 & 0.10% FOR SENSITIZATION & 0.25% FOR CHALLENGE IN THE MEST; 0.005, 0.01, 0.05, 0.10, & 0.25% FOR SENSITIZATION IN THE LLNA. DNFB (2, 4-DINITROFLUOROBENZENE) USED AS POSITIVE CONTROL AT 0.25% FOR SENSITIZATION AND CHALLENGE.

in vitro Testing

  • Bovine Corneal Opacity and Premeability Assay  (IVT20002A)  Completed 
    • Dose-Response Cytotoxicity Assay Using the EpiDermTM Skin Model  (IVT20002B)  Completed 
      • Neutral Red Uptake Bioassay  (IVT20002C)  Completed 
        • Cytotoxicity Assay Using MTT Reduction in Primary Rat Hepatocytes  (IVT20002D)  Completed