Testing Status of m-Nitrobenzoic acid M20341

 

CASRN: 121-92-6

Formula: C7-H5-N-O4

Synonyms/Common Names

  • 3-Nitrobenzoic acid (9CI)

Known Uses

Organic synthesis. Manufacturing of intermediates. Reagent for alkaloids and thorium.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C61767)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Feed)  (C61767)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 0.063, 1.0, M: 0, 0.125, 2.0 %.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (013799)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A12620)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (606292)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 
  • Salmonella  (929337)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 

Organ Systems Toxicity

  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Feed)  (RACB88105)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of meta-Nitrobenzoic Acid on CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: 0, .25, .5, 1., M2., 4.%; 0, .35, .75, 1.5%; 0, 1.5%; 0, .35, .75, 1.5%.