National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m20342

Testing Status of Hycanthone methanesulfonate - M20342

 

CASRN: 23255-93-8

Related: HYCANTHONE 3105-97-3

Formula: C20-H24-N2-O2-S.C-H4-O3-S

Synonyms/Common Names

  • 9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)-, monomethanesulfonate (salt) (9CI)

Known Uses

Used in treatment of schistosomiasis

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (497400)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Positive 

Organ Systems Toxicity

  • Total Reproductive Capacity (Gavage)  (TRC98020)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice: B6C3F1
    • Mice Female  +, INTERVAL 1
    • +, INTERVAL 1
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