National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m20406

Testing Status of Cyclosporin A - M20406

 

CASRN: 59865-13-3

Related: TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)

Formula: C62-H111-N11-O12

Synonyms/Common Names

  • Cyclosporine

Known Uses

Immunosuppressive, drug occurring naturally in fungus

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (923570)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 6 alternating days over a 12 day period Immunotoxicity (Gavage)  (IMM96014)  Completed 
    • Female Mice: C57BL/6
    • Dose: 0, 1, 5, 10, 50, 100 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.