National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m88005

Testing Status of Ethoxyquin - M88005

 

CASRN: 91-53-2

Formula: C14-H19-N-O

Synonyms/Common Names

  • 1,2-Dihydro-2,2,4-trimethyl-6-ethoxyquinoline
  • 6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinoline

Known Uses

Antioxidant in feed and food, antidegradation agent for rubber, insecticide; fertilizer, antiscald agent for apples & pears

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C90003)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.12, 0.25, 0.5, 0.75, 1% IN FEED; 5/GRP/SEX.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0218)  Completed 
    • Citation: Sanders JM, Burka LT, Matthews HB. Comparative metabolism and disposition of ethoxyquin in rat and mouse. I. Disposition. Xenobiotica. 1996 Jun;26(6):583-95.Pubmed Abstract
    • Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: 2.5, 25, 250 MG/KG.
  • Metabolism (Gavage)  (S0177)  Completed 
    • Citation: Burka LT, Sanders JM, Matthews HB. Comparative metabolism and disposition of ethoxyquin in rat and mouse. II. Metabolism. Xenobiotica. 1996 Jun;26(6):597-611.Pubmed Abstract
    • Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: 25 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (247323)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A23892)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (620987)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP92047)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 100, 400, 600, 800, OR 1000 MG/KG.
  • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP92048)  Completed 
    • Female Rabbit: New Zealand White
    • Dose: 0, 50, 200, 400, 600, OR 800 MG/KG.
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