National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m88006

Testing Status of Propyl-4-hydroxybenzoate - M88006

 

CASRN: 94-13-3

Formula: C10-H12-O3

Synonyms/Common Names

  • N-Propyl paraben
  • Propylparaben

Known Uses

Antifungal preservative of pharmaceuticals and food. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Planned Carcinogenicity/Toxicity

  • 14-Day Selected (C88006C)  

    Modified One-Generation

    • Conventional Teratology (Gavage) Selected (MOG88006B)  
      • Rats: Harlan Sprague-Dawley
    • F0 Generation (Gavage) Selected (MOG88006B)  
      • Rats: Harlan Sprague-Dawley
    • Fertility Assessment (Gavage) Selected (MOG88006B)  
      • Rats: Harlan Sprague-Dawley
    • 90 days Subchronic (Gavage) Selected (MOG88006B)  
      • Rats: Harlan Sprague-Dawley

    Genetic Toxicology

    • Salmonella  (810084)  Completed 
      •  Equivocal 
    • Salmonella  (A72946)  Completed 
      •  Negative 

    Toxicogenomics

    • Microarray Analysis (Gavage) Selected (T88006)  
      • Rats: Harlan Sprague-Dawley
    NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.