National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m88007

Testing Status of Butyl Paraben - M88007

 

CASRN: 94-26-8

Formula: C11-H14-O3

Synonyms/Common Names

  • Butylparaben
  • Butyl paraben
  • n-Butyl-p-hydroxybenzoate

Known Uses

Preservative in cosmetics, drug formulations, and some foods

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (K88007)  Completed 
    • Citation: Absorption, Distribution, Metabolism, Excretion (ADME) Chemical Disposition in Mammals CAS No. 94-26-8 n-Butyl -p-Hydroxybenzoate Biological Sample Method Development Analysis for n-Butyl-p-Hydroxybenzoate (Butylparaben) and Butyl 3,4-dihydroxybenzoate in Female Harlan Sprague-Dawley Rat Plasma with Cross Validation to Amniotic Fluid. November 5, 2013
    • Citation: Absorption, Distribution, Metabolism, Excretion (ADME) Chemical Disposition in Mammals n-Butyl-p-Hydroxybenzoate Preliminary Biological Sample Analysis Report Determination of n-Butyl-p-Hydroxybenzoate (Butylparaben) and 3-Hydroxybutylparaben in Rat Plasma, Amniotic Fluid, Fetus and Pup Homogenates. May 14, 2012
    • Citation: Final Study Report Disposition and Metabolism of n-Butyl-p-Hydroxybenzoate (CAS # 94-26-8) in Rats Following Dermal, Oral, and Intravenous Exposure Absorption, Distribution, Metabolism, Excretion (ADME) Chemical Disposition in Mammals. June 21, 2012
    • Male and Female Rats: Harlan Sprague-Dawley; Male Rats: Harlan Sprague-Dawley
    • Dose: gavage; 0, 10, 100, 1000 mg/kg. intravenous; 10 mg/kg. topical application; 100, 10 mg/kg.

Genetic Toxicology

  • Salmonella  (926250)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Maternal Transfer (Dosed-Feed)  (R88007C)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 1500, 5000, or 15000 ppm.
  • Continuous Breeding (Dosed-Feed)  (R88007B)  Completed 
    • RACB Main study
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 5000, 15000, or 40000 ppm.
  • Continuous Breeding (Dosed-Feed)  (R88007)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 5000, 10000, 20000, or 40000 ppm.

Toxicogenomics

  • Microarray Analysis (Gavage) Selected (T88007)  
    • Rats: Harlan Sprague-Dawley
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.