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Testing Status of Butyl Paraben M88007

 

CASRN: 94-26-8

Formula: C11-H14-O3

Synonyms/Common Names

  • Butylparaben
  • Butyl paraben
  • n-Butyl-p-hydroxybenzoate

Known Uses

Preservative in cosmetics, drug formulations, and some foods

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (K88007)  Completed 
    • Citation: Absorption, Distribution, Metabolism, Excretion (ADME) Chemical Disposition in Mammals CAS No. 94-26-8 n-Butyl -p-Hydroxybenzoate Biological Sample Method Development Analysis for n-Butyl-p-Hydroxybenzoate (Butylparaben) and Butyl 3,4-dihydroxybenzoate in Female Harlan Sprague-Dawley Rat Plasma with Cross Validation to Amniotic Fluid. November 5, 2013
    • Citation: Absorption, Distribution, Metabolism, Excretion (ADME) Chemical Disposition in Mammals n-Butyl-p-Hydroxybenzoate Preliminary Biological Sample Analysis Report Determination of n-Butyl-p-Hydroxybenzoate (Butylparaben) and 3-Hydroxybutylparaben in Rat Plasma, Amniotic Fluid, Fetus and Pup Homogenates. May 14, 2012
    • Citation: Final Study Report Disposition and Metabolism of n-Butyl-p-Hydroxybenzoate (CAS # 94-26-8) in Rats Following Dermal, Oral, and Intravenous Exposure Absorption, Distribution, Metabolism, Excretion (ADME) Chemical Disposition in Mammals. June 21, 2012
    • Citation: Mathews JM, Brown SS, Patel PR, Black SR, Banks TT, Etheridge AS, Fennell TR, Snyder RW, Blystone CR, Waidyanatha . Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application. Xenobiotica. 2013 Feb;43(2):169-81. Epub 2012 Jul 25.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male Rats: Harlan Sprague-Dawley
    • Dose: gavage; 0, 10, 100, 1000 mg/kg. intravenous; 10 mg/kg. topical application; 100, 10 mg/kg.

Genetic Toxicology

  • Salmonella  (926250)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Maternal Transfer (Dosed-Feed)  (R88007C)  Completed 
    • Citation: Roberts GK, Waidyanatha S, Kissling G, Fletcher BL, Silinski MAR, Fennell TR, Cunny HC, Robinson VG, Blystone CR. Exposure to Butyl Paraben during Gestation and Lactation in Harlan Sprague Dawley Rats via Dosed Feed. Toxicology Reports. 2016 Sep;3:774-783
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 1500, 5000, or 15000 ppm.
  • Continuous Breeding (Dosed-Feed)  (R88007B)  Completed 
    • RACB Main study
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 5000, 15000, or 40000 ppm.
  • Continuous Breeding (Dosed-Feed)  (R88007)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 5000, 10000, 20000, or 40000 ppm.

Toxicogenomics

  • Microarray Analysis (Gavage) Selected (T88007)  
    • Rats: Harlan Sprague-Dawley