National Toxicology Program

National Toxicology Program

Testing Status of 3,4-Dihydroxycinnamic acid - M88012


CASRN: 331-39-5

Formula: C9-H8-O4

Synonyms/Common Names

  • Caffeic acid
  • 4-(2-Carboxyethenyl)-1,2-dihydroxybenzene
  • 3,4-Dihydroxycinnamic acid
  • 2-Propenoic acid, 3-(3,4-dihydroxyphenyl)-

Known Uses

Plants containing caffeic acid may be used for medicinal purposes. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Micronucleus  (A90940)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (787406)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.