National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m88022

Testing Status of Chemical mixture - drinking water contaminants - M88022

 

CASRN: CHEMMIXH2O

Formula: N/F

Secondary:

  • 67-64-1 - Acetone
  • 11096-82-5 - Arochlor 1260 (9CI)
  • 1327-53-3 - Arsenic trioxide
  • 71-43-2 - Benzene
  • 5743-04-4 - Cadmium acetate dihydrate
  • 10108-64-2 - Cadmium chloride
  • 56-23-5 - Carbon tetrachloride
  • 108-90-7 - Chlorobenzene
  • 67-66-3 - Chloroform
  • 1333-82-0 - Chromium trioxide
  • 10060-12-5 - Chromium chloride hexahydrate (9CI)
  • 75-34-3 - 1,1-Dichloroethane
  • 107-06-2 - 1,2-Dichloroethane
  • 156-60-5 - trans-1,2-Dichloroethylene
  • 117-81-7 - Di(2-ethylhexyl) Phthalate
  • 100-41-4 - Ethylbenzene
  • 71-55-6 - Halogenated ethanes CS (1,1,1-Trichloroethane)
  • 301-04-2 - Lead(2+) acetate
  • 7487-94-7 - Mercuric chloride
  • 75-09-2 - Methylene chloride
  • 6018-89-9 - Nickel acetate tetrahydrate
  • 7786-81-4 - Nickel sulfate
  • 108-95-2 - Phenol
  • 127-18-4 - Tetrachloroethylene
  • 108-88-3 - Toluene
  • 108-88-3 - Toluene (technical)
  • 117-81-7 - Transgenic model evaluation (Di(2-ethylhexyl) phthalate)
  • 71-43-2 - Transgenic model evaluation II (Benzene)
  • 75-25-2 - Tribromomethane
  • 71-55-6 - 1,1,1-Trichloroethane
  • 79-01-6 - Trichloroethylene
  • 75-35-4 - Vinylidene Chloride
  • 67-66-3 - Water disinfection byproducts (Chloroform)
  • 1330-20-7 - Xylenes (mixed)

Known Uses

Chemicals found in drinking water

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C62420)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 26 weeks (Dosed-Water)  (C62420)  Report Complete 
    • TOX-35 (NIH Number: 93-3384)
      Toxicity Studies of a Chemical Mixture of 25 Groundwater Contaminants Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 11, 38, 113, & 378 PPM; 20/GROUP.

Genetic Toxicology

  • Micronucleus  (A10845)  Completed 
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A18666)  Completed 
    • Rats/Mice: B6C3F1
    • Male Negative 
    • Female Equivocal 
  • Sister Chromatid Exchanges  (A18666)  Completed 
    • Mice
    • Sister Chromatid  Negative (Nonstandard Protocol) 

Organ Systems Toxicity

  • 27 weeks Continuous Breeding (Legacy) (Dosed-Water)  (RACB88036)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of a Chemical MIxture in CD-1 Swiss Mice-Laboratory Supplement
    • Citation: Final Report on the Reproductive Toxicity of a Chemical Mixture in CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: N/A; OX,10X,50X,100X; N/A; 0X,10X,50X,100X.
  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Water)  (RACB90062)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of a Complex Mixture of Groundwater Contaminants in Sprague-Dawley Rats
    • Male and Female Rats: Sprague Dawley
    • Dose: N/A; 0,10X,50X,100XL; N/A; 0,100X.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.