National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m88037

Testing Status of Cyclohexanone oxime - M88037

 

CASRN: 100-64-1

Related: 2-BUTANONE OXIME (96-29-7)

Formula: C6-H11-N-O

Synonyms/Common Names

  • (Hydroxyimino)cyclohexane

Known Uses

Intermediate for the production of caprolactam, which is used to form nylon.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C88047)  Completed 
    • Mice: B6C3F1
    • Dose: M: 0, 106, 312, 625, 1250, OR 2500 PPM; 5/GROUP.
  • 13 weeks (Dosed-Water)  (C88047)  Report Complete 
    • TOX-50 (NIH Number: 96-3934)  (Tox Peer Review 03/00/1995A )
      Toxicity Studies of Cyclohexanone Oxime in B6C3F1 Mice (Drinking Water Studies) (CASRN 100-64-1)
    • Mice: B6C3F1
    • Dose: 0, 625, 1250, 2500, 5000, OR 10000 PPM; 10/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Topical Application)  (S0707)  Completed 
    • Citation: Parmar D, Burka LT. Metabolism and disposition of cyclohexanone oxime in male F-344 rats. Drug Metab Dispos. 1991 Nov-Dec;19(6):1101-7.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (A35717)  Completed 
    • Sister Chromatid Exchange Not Tested 
    • Chromosome Aberrations Equivocal 
  • Micronucleus  (A45594)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A87965)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (152023)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.