Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Cyclohexanone oxime M88037

 

CASRN: 100-64-1

Formula: C6-H11-N-O

Synonyms/Common Names

  • (Hydroxyimino)cyclohexane

Known Uses

Intermediate for the production of caprolactam, which is used to form nylon.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C88047)  Completed 
    • Mice: B6C3F1
    • Dose: M: 0, 106, 312, 625, 1250, OR 2500 PPM; 5/GROUP.
  • 13 weeks (Dosed-Water)  (C88047)  Completed 
    • Mice: B6C3F1
    • Dose: 0, 625, 1250, 2500, 5000, OR 10000 PPM; 10/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Topical Application)  (S0707)  Completed 
    • Citation: Parmar D, Burka LT. Metabolism and disposition of cyclohexanone oxime in male F-344 rats. Drug Metab Dispos. 1991 Nov-Dec;19(6):1101-7.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: ORAL: 1, 10, AND 30 MG/KG IN 5 ML/KG OF DOSING SOLUTION. DERMAL: 30 MG/KG AND APPLIED AT 0.2 ML/KG TO THE INTERSCAPULAR AREA..

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (A35717)  Completed 
    • Sister Chromatid Exchange Not Tested 
    • Chromosome Aberrations Equivocal 
  • Micronucleus  (A45594)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A87965)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (152023)  Completed 
    •  Positive