National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m88067

Testing Status of Glyphosate - M88067

 

CASRN: 1071-83-6

Related: See CAS 38641-94-0

Formula: C3-H8-N-O5-P

Synonyms/Common Names

  • Glycine, N-(phosphonomethyl)- (8CI)(9CI)
  • Roundup®

Known Uses

Agricultural chemical. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Feed)  (C62011)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 4 weeks (Dosed-Feed)  (C62011B)  Report Complete 
    • TOX-16 (NIH Number: 92-3135)
      Toxicity Studies of Glyphosate (CASRN 1071-83-6) Administered in Dosed Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N
    • Dose: Male rats: vehicle, vehicle + glyphosate 50000 ppm, glyphosate 50000 ppm + propranolol (1.2 mg/kg/day) isoproterenol pump (1 mg/kg/day: positive control), isoproterenol + propranolol pump (1, 1.2 mg/kg/day: blocking control) for 14 days.
  • 13 weeks (Dosed-Feed)  (C62011)  Report Complete 
    • TOX-16 (NIH Number: 92-3135)
      Toxicity Studies of Glyphosate (CASRN 1071-83-6) Administered in Dosed Feed to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M:0, 3125, 6250, 12500, 25000, 50000PPM/10 PER GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0095)  Completed 
    • Citation: Final Report Chemical Disposition In Mammals: Glyphosate Absorption In The Male Fischer Rat
    • Male Rats: F344/N
    • Dose: 5.6, 56 MG/KG.

Genetic Toxicology

  • Micronucleus  (A34848)  Completed 
    • Citation: Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (149350)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.