National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m88086

Testing Status of Bleomycin - M88086

 

CASRN: 11056-06-7

Formula: C55-H84-N20-O21-S2.C55-H84-N17-O21-S3

Synonyms/Common Names

  • Bleomycin

Known Uses

Anti-neoplastic agent

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • Dominant Lethal (Female) (Inhalation)  (DLF013)  Completed 
    • Citation: Sudman, P.D., Rutledge, J.C., Bishop, J.B., and Generoso, W.M. Bleomycin: Female-specific dominant lethal response in mice. Mutation Res. 296: 143-156 (1992).
    • Female Mice: SEC X C57BL
    • Mice Female Positive 
  • Dominant Lethal (Female) (Dosed-Water)  (DLF014)  Completed 
    • Citation: Sudman, P.D., Rutledge, J.C., Bishop, J.B., and Generoso, W.M. Bleomycin: Female-specific dominant lethal response in mice. Mutation Res. 296: 143-156 (1992).
    • Female Mice: C3H X C57BL
    • Mice Female Positive 
  • Dominant Lethal (Male) (Dosed-Feed)  (DLM012)  Completed 
    • Citation: Sudman, P.D., Rutledge, J.C., Bishop, J.B., and Generoso, W.M. Bleomycin: Female-specific dominant lethal response in mice. Mutation Res. 296: 143-156 (1992).
    • Male Mice: 101 X C3H
    • Mice Male Negative 
  • Morphological Specific Locus (Dosed-Feed)  (MSLT96002)  Completed 
    • Citation: Russell, LB, Hunsicker, PR, and Shelby, MD. Chlorambucil and bleomycin induce mutations in the specific-locus test in female mice. Mutation Res. 358: 25-35 (1996).
    • Female Mice: C3H X 101
    • Mice Female Positive 
  • Total Reproductive Capacity (Gavage)  (TRC98045)  Completed 
    • Citation: Sudman, P.D. and Generoso, W.M. Female-specific mutagenic response of mice to hycanthone. Mutation Res. 246: 31-43 (1991).
    • Female Mice
    • Mice Female Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.