National Toxicology Program

National Toxicology Program

Testing Status of 1,4-Butanediol - M88088


CASRN: 110-63-4

Formula: C4-H10-O2

Synonyms/Common Names

  • Tetramethylene glycol

Known Uses

Chemical intermediate for tetrahydrofuran, monomer for polybutylene terephthalate resins, intermediate in polyester resins, used in production of 1,4-butanediol dimethanesulfonate. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • Special (Dosed-Feed)  (C88029)  Report Complete 
    • TOX-54 (NIH Number: 96-3932)  (Tox Peer Review 06/21/1995A )
      Summary Report on the Metabolism, Disposition and Toxicity of 1,4-Butanediol (CASRN 110-63-4)
    • Rats: F344/N

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0162)  Completed 
    • Male Rats: F344/N
    • Dose: 4, 40, 120, 400 MG/KG.

Genetic Toxicology

  • Salmonella  (566126)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Gavage)  (TER90030)  Completed 
    • Citation: Final Report on the Developmental Toxicity of 1,4-Butanediol in Swiss (CD-1) Mice
    • Citation: Final Report on the Developmental Toxicity of 1,4-Butanediol in Swiss (CD-1) Mice
    • Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 100, 300, 600 MG/KG/DAY.
  • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP90001)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: 0, 100, 400, 600, 800, OR 1000 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.