National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m88089

Testing Status of Butanal oxime - M88089

 

CASRN: 110-69-0

Formula: C4-H9-N-O

Synonyms/Common Names

  • Butyraldehyde oxime

Known Uses

As an antiskinning agent in varnishes, paints, inks, and similar products. Potential use as corrosion inhibitor in steam-generating systems (ex summ 7/88).

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Dosed-Water)  (C88045)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R & M: 0, 312, 625, 1250, 2500, OR 5000 PPM; 5/SEX/SPECIES/GROUP.
  • 13 weeks (Dosed-Water)  (C88045)  Report Complete 
    • TOX-69 (NIH Number: 04-4417)  (Tox Peer Review 03/20/2002A )
      Toxicity Studies of Butanal Oxime (CASRN 110-69-0) Administered in Drinking Water and by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 25, 50, 100, 200, OR 600 MG/KG; 10/SEX/SPECIES/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (S0108)  Completed 
    • Citation: Disposition of Butanal Oxime (BOX) in Rats After Oral, Intravenous and Dermal Administration. Project Report No. 15. Dates of Study: October 1989 - February 1990. Studies of Chemical Disposition in Mammals.
    • Male Rats: F344/N

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (A22486)  Completed 
    • Chromosome Aberrations Positive 
  • Micronucleus  (A87268)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Positive 
  • Salmonella  (459847)  Completed 
    •  Weakly Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.