National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m88111

Testing Status of Scopolamine hydrobromide - M88111

 

CASRN: 114-49-8

Formula: C17-H21-N-O4.Br-H

Synonyms/Common Names

  • Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester, hydrobromide, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))- (9CI)

Known Uses

Anticholinergic, vet. Sedative, preanesthetic, control of motion sickness, isolated from several species of solanaceae (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0264)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Gavage)  (TER85106)  Completed 
    • Citation: Teratologic Evaluation of Scopolamine Hydrobromide Administered to CD Rats on Gestational Days
    • Female Rats: Sprague Dawley
    • Rats Maternal Positive 
    • Rats Fetal Positive 
    • Dose: 0, 10, 100, 450, 900 MG/KG/DAY.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER85107)  Completed 
    • Citation: Teratologic Evaluation of Scopolamine Hydrobromide Administered to CD-1 Mice on Gestational Days 6 through 15
    • Female Mice: Swiss
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 10, 100, 450, 900 MG/KG/DAY.
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