Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of trans-Cinnamaldehyde M88146

 

CASRN: 14371-10-9

Formula: C9-H8-O

Synonyms/Common Names

  • 2-Propenal, 3-phenyl-, (E)- (9CI)

Known Uses

Naturally occurring derivative of cinnamon bark, a flavoring. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C56111E)  Completed 
    • Rats: F344/N
    • Dose: FEMALE RATS ONLY: 0, 235, 470, 940, 1410 MG/KG/DAY.
  • 13 weeks (Microencapsulation in Feed)  (C56111B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.41, 0.82, 1.65 OR 3.30% OR 4100, 8200, 16500 OR 33000 PPM; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Microencapsulation in Feed)  (C56111B)  Completed 
    • TR-514 (NIH Number: 04-4448)  (Peer Review Approval 09/05/2002A )
      Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0 (UNTREATED), 0 (VEHICLE), 1, 000, 2, 100, or 4, 100 ppm; 50/SEX/DOSE (equivalent to 0.1%, 0.21%, or 0.41%). R&M: 0 (UNTREATED), 0 (VEHICLE), 1, 000, 2, 100, or 4, 100 ppm; 50/SEX/DOSE (equivalent to 0.1%, 0.21%, or 0.41%).

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (290481)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (896321)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Micronucleus  (A19689)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (B19689)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Negative 
  • Salmonella  (579971)  Completed 
    •  Weakly Positive 
  • Salmonella  (816373)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative