National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m88146

Testing Status of trans-Cinnamaldehyde - M88146

 

CASRN: 14371-10-9

Related: CINNAMALDEHYDE (104-55-2)

Formula: C9-H8-O

Synonyms/Common Names

  • 2-Propenal, 3-phenyl-, (E)- (9CI)

Known Uses

Naturally occurring derivative of cinnamon bark, a flavoring. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Gavage)  (C56111E)  Completed 
    • Rats: F344/N
    • Dose: FEMALE RATS ONLY: 0, 235, 470, 940, 1410 MG/KG/DAY.
  • 13 weeks (Microencapsulation in Feed)  (C56111B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.41, 0.82, 1.65 OR 3.30% OR 4100, 8200, 16500 OR 33000 PPM; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Microencapsulation in Feed)  (C56111B)  Report Complete 
    • TR-514 (NIH Number: 04-4448)  (Peer Review Approval 09/05/2002A )
      Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: 0 (UNTREATED), 0 (VEHICLE), 1,000, 2,100, or 4,100 ppm; 50/SEX/DOSE (equivalent to 0.1%, 0.21%, or 0.41%). R&M: 0 (UNTREATED), 0 (VEHICLE), 1,000, 2,100, or 4,100 ppm; 50/SEX/DOSE (equivalent to 0.1%, 0.21%, or 0.41%).

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (290481)  Completed 
    • Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Drosophila  (896321)  Completed 
    • Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
    • Sex-Linked Recessive Lethal Positive 
    • Reciprocal Translocation Negative 
  • Micronucleus  (A19689)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (B19689)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Negative 
  • Salmonella  (579971)  Completed 
    •  Weakly Positive 
  • Salmonella  (816373)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.