Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Aspartame M88167

 

CASRN: 22839-47-0

Formula: C14-H18-N2-O5

Synonyms/Common Names

  • L-Phenylalanine, N-L-alpha-aspartyl-, 1-methyl ester

Known Uses

Artificial sweetener

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Micronucleus  (A20159)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Male Negative 
    • Female Positive 
  • Micronucleus  (A37530)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A56067)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A66023)  Completed 
    • Mice: P16(Ink4a)/(+/-) (C57BL/6)
    • Male Negative 
    • Female Negative 
  • Micronucleus  (F37530)  Completed 
    • Rats: Fischer 344
    • Male Negative 
    • Female NA 
  • Salmonella  (A13862)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Neurotoxicology Assessment (Gavage)  (NTA94035)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male Rats: F344/N