Testing Status of Dipropylene glycol M88175
CASRN: 25265-71-8
Formula: C6-H14-O3
Synonyms/Common Names
- Oxybispropanol
Known Uses
Intermediate for polyester resins, solvent extraction of aromatic hydrocarbons, steam set printing inks, stabilizer in cosmetics
Chemical Properties
Toxicity Effects (HSDB)
Short-Term Toxicity
- 2 weeks (Dosed-Water)
(C88031)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 0.5, 1.0, 2.0, 4.0, OR 8.0 % (5/S/S).
- 13 weeks (Dosed-Water)
(C88031)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 0.5, 1.0, 2.0, 4.0 OR 8.0 % (10/S/S).
Long-Term Carcinogenicity
- 2 years (Dosed-Water)
(C88031B)
Completed
- TR-511 (NIH Number: 04-4445)
(Peer Review Approval 09/05/2002A )
Toxicology and Carcinogenesis Studies of Dipropylene Glycol (CASRN 25265-71-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R: 0, 0.25, 1.0, OR 4.0% M: 0, 1.0, 2.0, OR 4.0%; 50/SEX/DOSE. R: 0, 2, 500, 10, 000, or 10, 000 ppm; M: 0, 10, 000, 20, 000 or 40, 000 ppm; 50/SEX/DOSE.
- TR-511 (NIH Number: 04-4445)
(Peer Review Approval 09/05/2002A )
Genetic Toxicology
- Micronucleus
(A31713)
Completed
- Mice
- Male Not a Valid Test
- Salmonella
(850639)
Completed
- Negative
Organ Systems Toxicity
- 6 to 19 GD Conventional Teratology (Gavage)
(TER90014)
Completed
- Citation: Final Report on the Developmental Toxicity of Dipropylene Glycol in New Zealand White Rabbits
- Rabbit: New Zealand White
- Rabbits Maternal Negative
- Rabbits Fetal Negative
- Dose: 0, 200, 400, 800, 1200 MG/KG/DAY.
- 6 to 15 GD Conventional Teratology (Gavage)
(TER91013)
Completed
- Citation: Final Report on the Developmental Toxicity of Dipropylene Glycol in Sprague-Dawley (CD) Rats
- Rats: Sprague Dawley
- Rats Maternal Positive
- Rats Fetal Positive
- Dose: 0, 800, 2000, 5000 MG/KG/DAY.
- 6 to 15 GD Teratology Pilot Studies (Gavage)
(TRP90005)
Completed
- Female Rats: Sprague Dawley
- Dose: 0, 800, 1500, 3000, 5000, OR 8000 MG/KG.
- 6 to 19 GD Teratology Pilot Studies (Gavage)
(TRP90006)
Completed
- Female Rabbit: New Zealand White
- Dose: 0, 200, 800, 1500, 3000, OR 5000 MG/KG.