National Toxicology Program

Testing Status of Dipropylene glycol - M88175

CASRN: 25265-71-8

Formula: C6-H14-O3

Synonyms/Common Names

• Oxybispropanol

Known Uses

Intermediate for polyester resins, solvent extraction of aromatic hydrocarbons, steam set printing inks, stabilizer in cosmetics

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

• 2 weeks (Dosed-Water)  (C88031)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.5, 1.0, 2.0, 4.0, OR 8.0 % (5/S/S).
• 13 weeks (Dosed-Water)  (C88031)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.5, 1.0, 2.0, 4.0 OR 8.0 % (10/S/S).

Long-Term Carcinogenicity

• 2 years (Dosed-Water)  (C88031B)  Report Complete 
  • TR-511 (NIH Number: 04-4445)  (Peer Review Approval 09/05/2002A )
    Toxicology and Carcinogenesis Studies of Dipropylene Glycol (CASRN 25265-71-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
  • Male Rats No Evidence 
  • Female Rats No Evidence 
  • Male Mice No Evidence 
  • Female Mice No Evidence 
  • Dose: R: 0, 0.25, 1.0, OR 4.0% M: 0, 1.0, 2.0, OR 4.0%; 50/SEX/DOSE. R: 0, 2, 500, 10, 000, or 10, 000 ppm; M: 0, 10, 000, 20, 000 or 40, 000 ppm; 50/SEX/DOSE.

Genetic Toxicology

• Micronucleus  (A31713)  Completed 
  • Mice
  • Male Not a Valid Test 
• Salmonella  (850639)  Completed 
  •  Negative 

Organ Systems Toxicity

• 6 to 19 GD Conventional Teratology (Gavage)  (TER90014)  Completed 
  • Citation: Final Report on the Developmental Toxicity of Dipropylene Glycol in New Zealand White Rabbits
  • Rabbit: New Zealand White
  • Rabbits Maternal Negative 
  • Rabbits Fetal Negative 
  • Dose: 0, 200, 400, 800, 1200 MG/KG/DAY.
• 6 to 15 GD Conventional Teratology (Gavage)  (TER91013)  Completed 
  • Citation: Final Report on the Developmental Toxicity of Dipropylene Glycol in Sprague-Dawley (CD) Rats
  • Rats: Sprague Dawley
  • Rats Maternal Positive 
  • Rats Fetal Positive 
  • Dose: 0, 800, 2000, 5000 MG/KG/DAY.
• 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP90005)  Completed 
  • Female Rats: Sprague Dawley
  • Dose: 0, 800, 1500, 3000, 5000, OR 8000 MG/KG.
• 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP90006)  Completed 
  • Female Rabbit: New Zealand White
  • Dose: 0, 200, 800, 1500, 3000, OR 5000 MG/KG.