Testing Status of Adriamycin, hydrochloride M88176

 

CASRN: 25316-40-9

Formula: C27-H29-N-O11.Cl-H

Synonyms/Common Names

  • Doxorubicin
  • Doxorubicin hydrochloride
  • 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)-

Known Uses

Pharmaceutical, chemotherapeutic (adriamycin isolated from streptomyces)

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Micronucleus  (A31423)  Completed 
    • Mice: B6C3F1
    • Male Positive 

Organ Systems Toxicity

  • Total Reproductive Capacity (Intravenous)  (TRC98002)  Completed 
    • Citation: Bishop, JB, Morris, RW, Seely, JC, Hughes, LA, Cain, KT, Generoso, WM. Alterations in the Reproductive Patterns of Female Mice Exposed to Xenobiotics. Fund. and Appl. Tox. 40: 191-204 (1997).
    • Female Mice
    • Mice Female Positive