Testing Status of 1,2,3,7,8-Pentachlorodibenzofuran (PCDF) M88217

 

CASRN: 57117-41-6

Formula: C12-H3-Cl5-O

Synonyms/Common Names

  • PCDF

Known Uses

Ubiquitous environmental contaminant; little known of its toxicity; potential for human exposure; very stable and resistant to chemical degradation. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0170)  Completed 
    • Citation: Brewster DW, Banks YB, Clark AM, Birnbaum LS. Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three polychlorinated dibenzofurans. Toxicol Appl Pharmacol. 1989 Jan;97(1):156-66.Pubmed Abstract
    • Male Rats: F344/N
  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0521)  Completed 
    • Citation: Brewster DW, Birnbaum LS. Disposition of 1,2,3,7,8-pentachlorodibenzofuran in the rat. Toxicol Appl Pharmacol. 1988 Sep 30;95(3):490-8.Pubmed Abstract
    • Male Rats: F344/N

Organ Systems Toxicity

  • Single dose Immunotoxicity (Gavage)  (I88217)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 0.3, 0.9, 1.5, 3 and 9 ug/ml.

Toxicogenomics

  • Microarray Analysis  (T88217)  Completed