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Testing Status of p,p'-Dichlorodiphenyl sulfone M882470

 

CASRN: 80-07-9

Formula: C12-H8-Cl2-O2-S

Synonyms/Common Names

  • 1,1'-Sulfonylbis(4-chlorobenzene)

Known Uses

Starting material in production of plastics

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Dosed-Feed)  (C88120)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 30, 100, 300, 1000, & 3000 PPM; 10/GRP/SEX.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C88120B)  Completed 
    • TR-501 (NIH Number: 01-4435)  (Peer Review Approval 05/18/2000A )
      Toxicology and Carcinogenesis Studies of p,p'-Dichlorodiphenyl Sulfone (CASRN 80-07-9) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: MR: 0, 10, 30, OR 100 PPM; FR & MICE: 0, 30, 100, OR 300 PPM; 50/SEX/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0160)  Completed 
    • Citation: Absorption and Disposition of [14C]p,p'-Dichlorodiphenyl Sulfone (DDS) Administered to F344 Rats. January 1992 - December 1994. Studies of Chemical Disposition in Mammals. December 6, 1994
    • Male Rats: F344/N
    • Dose: 10, 100, 1000 MG/KG.
  • Absorption Disposition Metabolism Elimination (Dosed-Feed)  (S0595)  Completed 
    • Citation: Mathews JM, Black SL, Matthews HB. p,p'-Dichlorodiphenyl sulfone metabolism and disposition in rats. Drug Metab Dispos. 1996 May;24(5):579-87.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: IV:10 mg/kg.
  • Toxicokinetic Study (Intravenous)  (S0631)  Completed 
    • Citation: Preliminary Toxicokinetic Study Report 4,4'-Dichlorodiphenyl Sulfone in Male F344 Rat Plasma. September 27, 1996.
    • Male Rats: F344/N
    • Dose: 1.0 mg/kg.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (133717)  Completed 
    • Sister Chromatid Exchange Equivocal 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A64289)  Completed 
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (147825)  Completed 
    •  Negative