National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m882472

Testing Status of Indium phosphide - M882472

 

CASRN: 22398-80-7

Formula: In-P

Synonyms/Common Names

  • Indium phosphide (InP)

Known Uses

Used in electronics industry; in semiconductor devices, injector lasers, and solar cells. Proposed to replace silicon in computer microchips.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 3 days (Inhalation)  (C88124)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 100 OR 300 MG/M3; 10/SEX/GROUP (NOSE ONLY).
  • 13 weeks (Inhalation)  (C88124)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 1, 3, 10, 30, OR 100 MG/M3; 10/SEX/GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C88124)  Report Complete 
    • TR-499 (NIH Number: 01-4433)  (Peer Review Approval 05/18/2000A )
      Toxicology and Carcinogenesis Studies of Indium Phosphide (CASRN 22398-80-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 0.03, 0.1, OR 0.3 MG/M3.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0260)  Completed 
    • Male Rats
    • Dose: 10 MG/KG.

Genetic Toxicology

  • Micronucleus  (A49283)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
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