National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m882479

Testing Status of Trimethylolpropane triacrylate - M882479

 

CASRN: 15625-89-5

Formula: C15-H20-O6

Synonyms/Common Names

  • Acrylic acid, triester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol
  • 2-ETAC
  • 2-Ethyl-2-(hydroxymethyl)-1,3-propanediol triacrylate
  • 2-Ethyl-2-(((2-oxo-2-propenyl)oxy)methyl)-1,3-propanediyl ester (9CI)
  • TMPTA

Known Uses

Used in the production of ultraviolet-curable inks, electron beam irradiation-curable coatings, & polymers & resins; as a component of photopolymer & flexographic printing plates & photoresists; & as an ingredient in acrylic glues & anaerobic sealants. Also used in paper & wood impregnates, wire & cable extrusion, polymer-impregnated concrete, & polymer concrete structural composites.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C88133)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 12.5, 25, 50, 100, OR 200 MG/KG.
  • 26 weeks (Topical Application)  (C88133B)  Report Complete 
    • GMM-03 (NIH Number: 06-4450)  (Peer Review Approval 09/06/2002A )
      Toxicology Studies of Trimethylolpropane Triacrylate (Technical Grade) (CASRN 15625-89-5) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 0.75, 1.5, 3, 6, OR 12 MG/KG; 15/SEX.
  • 13 weeks (Topical Application)  (C88133)  Report Complete 
    • GMM-03 (NIH Number: 06-4450)  (Peer Review Approval 09/06/2002A )
      Toxicology Studies of Trimethylolpropane Triacrylate (Technical Grade) (CASRN 15625-89-5) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.75, 1.5, 3, 6, OR 12 MG/KG; 10/SEX/SPECIES/DOSE.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C88133C)  Report Complete 
    • TR-576 (NIH Number: 12-5918)  (Peer Review Approval 02/08/2012A )
      Toxicology and Carcinogenesis Studies of Trimethylolpropane triacrylate (CASRN 15625-89-5) in F344/N Rats (Topical Application Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Some Evidence 
    • Dose: R&M: 0, 0.3, 1.0, OR 3.0 MG/KG; 65/SEX/SPECIES/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (Intravenous; Topical Application)  (S0547)  Completed 
    • Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: IV: RAT 10 MG/KG MOUSE ??; DERMAL: RAT 1.5, 15, 150 MG/KG, MOUSE 1.2 MG/KG.

Genetic Toxicology

  • Micronucleus  (A10307)  Completed 
    • Mice: Tg.AC
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A71420)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A46551)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 4 days Immunotoxicity (Topical Application)  (IMM95008)  Completed 
    • Female Mice: B6C3F1
    • Dose: MEST: 0.01, 0.03, 0.1 & 0.3% IN 99.8% ACETONE AND 1.0% FOR CHALLENGE LLNA: 0.03, 0.1, 0.15, 0.3 AND 1.0 FOR SENSITIZATION (0.25% DNFB POSITIVE CONTROL AND 0.5 OR 0.25% FOR CHALLENGE).
  • Immunotoxicity (Topical Application)  (IMM97003)  Completed 
    • Female Mice: BALB/c
    • Dose: 0.01, 0.05 AND 0.1% IN ACETONE FOR SENSITIZATION, AND 0.25% FOR CHALLENGE IN THE MEST AND 0.05, 0.01, AND 0.25% FOR SENSITIZATION IN THE LLNA.
  • Teratology Pilot Studies (Gavage)  (TRP92051)  Completed 
    • Rats
    • Dose: 0, 100, 500, 1000, 2000, 3000 MG/KG/DAY.
  • Teratology Pilot Studies (Gavage)  (TRP92052)  Completed 
    • Rabbit: New Zealand White
    • Dose: 0, 50, 250, 1000, 1500, 2000 MG/KG/DAY.

in vitro Testing

  • Bovine Corneal Opacity and Premeability Assay  (IVT20001A)  Completed 
    • Dose-Response Cytotoxicity Assay Using the EpiDermTM Skin Model  (IVT20001B)  Completed 
      • Neutral Red Uptake Bioassay  (IVT20001C)  Completed 
        • Cytotoxicity Assay Using MTT Reduction in Primary Rat Hepatocytes  (IVT20001D)  Completed 
          NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.