National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m882484

Testing Status of Dichloroacetic acid - M882484

 

CASRN: 79-43-6

Related: TRICHLOROACETIC ACID

Formula: C2-H2-Cl2-O2

Synonyms/Common Names

  • Bichloracetic acid
  • DCA
  • Dichloracetic acid
  • Dichloroethanoic acid

Known Uses

Breakdown product of drinking water disinfectants, astringent, use in treatment of lactic acidosis, keratolytic agent (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Genetic Toxicology

  • Micronucleus  (A15985)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A67778)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Positive 
  • Micronucleus  (A72842)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A91472)  Completed 
    • Mice: P53 +/- (C57BL/6)
    • Male Negative 
    • Female Negative 
  • Salmonella  (024933)  Completed 
    •  Positive 
  • Salmonella  (A67820)  Completed 
    •  Positive 

Organ Systems Toxicity

  • less than or equal to 28 days Spermiation Inhibition (Gavage)  (RACB93158)  Completed 
    • Male Rats: F344/N
    • Dose: </= 125 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.