Testing Status of p-Chloroaniline hydrochloride M882492

 

CASRN: 20265-96-7

Formula: C6-H6-Cl-N.Cl-H

Synonyms/Common Names

  • 4-Chlorobenzenamine hydrochloride

Known Uses

An aromatic amine widely used in the dye, chemical, textile, rubber and other industries; as an intermediate in the manufacture of dyes and pigments; detected as a degradation product in some pharmaceutical preparations.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C02039B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C02039B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 5, 80, M: 0, 7.5, 120 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C02039B)  Report Complete 
    • TR-351 (NIH Number: 89-2806)  (Peer Review Approval 04/18/1988A )
      Toxicology and Carcinogenesis Studies of para-Chloroaniline Hydrochloride (CASRN 20265-96-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Some Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 2, 6, 18, M: 0, 3, 10, 30 MG/KG/50 PER GROUP.

Genetic Toxicology

  • Micronucleus  (A79778)  Completed 
    • Mice: B6C3F1
    • Male Positive