National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m88290

Testing Status of 2',3'-Dideoxycytidine - M88290

 

CASRN: 7481-89-2

Formula: C9-H13-N3-O3

Synonyms/Common Names

  • Cytidine, 2',3'-dideoxy-
  • DDC (AIDS Initiative)
  • 2',3'-Dideoxycytidine (AIDS Initiative)

Known Uses

Experimental drug used in the treatment of AIDS

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Gavage)  (C88073C)  Completed 
    • Mice: NIH Swiss
  • 13 & 26 weeks (Gavage)  (C88073B)  Completed 
    • Mice: B6C3F1
    • Dose: FEMALE MICE ONLY: 500 0R 1000 MG/KG/DAY.
  • 26 weeks (Gavage)  (C88073C)  Completed 
    • Mice: B6C3F1; Mice: NIH Swiss
  • 13 weeks (Gavage)  (C88073)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: (GIVEN AS DIVIDED DOSE AT 9AM AND 3PM) 0, 125, 250, 500, 1000, OR 2000 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (955544)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (029073)  Completed 
    • Citation: Phillips, M.D., Nascimbeni, B., Tice, R.R., and Shelby, M.D. Induction of MN in Mouse BM cells: An evaluation of nucleoside analogues used in the treatment of Aids. Environ. Molec. Mutag. Vol. 18 (1991) 168-183
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (258838)  Completed 
    •  Weakly Positive 

Organ Systems Toxicity

  • Continuous Breeding (Legacy) (Dosed-Feed)  (RACB92125)  Completed 
    • Male and Female Monkey: Rhesus
  • 1 to 31 Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB92122)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; 0,200,400,1000 MG/KG; N/A; N/A.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER87145)  Completed 
    • Mice: C57BL/6
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, 200, 400, 1000, 2000 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.