National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m88291

Testing Status of 2',3'-Dideoxyinosine (AIDS Initiative) - M88291

 

CASRN: 69655-05-6

Related: 124516-24-1

Formula: C10-H12-N4-O3

Synonyms/Common Names

  • DDI (AIDS Initiative)
  • Inosine, 2',3'-dideoxy-

Known Uses

Experimental drug used in the treatment of AIDS, hypoxanthine nucleoside with anti-viral activity (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (705410)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (865388)  Completed 
    • Citation: Phillips, M.D., Nascimbeni, B., Tice, R.R., and Shelby, M.D. Induction of MN in Mouse BM cells: An evaluation of nucleoside analogues used in the treatment of Aids. Environ. Molec. Mutag. Vol. 18 (1991) 168-183
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A08622)  Completed 
    • Citation: Witt KL, Tice RR, Wolfe GW, Bishop JB. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 2004;44(4):321-8.
    • Mice: Swiss CD-1
    • Male Negative 
  • Micronucleus  (A20001)  Completed 
    • Citation: Witt KL, Tice RR, Wolfe GW, Bishop JB. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 2004;44(4):321-8.
    • Mice: Swiss CD-1
    • Female Negative 
  • Micronucleus  (A90144)  Completed 
    • Citation: Witt KL, Tice RR, Wolfe GW, Bishop JB. Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment. Environ Mol Mutagen. 2004;44(4):321-8.
    • Mice: Swiss CD-1
    • Male Negative 
  • Salmonella  (783382)  Completed 
    •  Weakly Positive 

Organ Systems Toxicity

  • 6 month Immunotoxicity (Gavage)  (IMM94006)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 100, 250, 500, OR 1000 MG/KG/DAY.
  • 14 or 28 days Immunotoxicity (Gavage)  (IMM96001)  Completed 
    • Female Mice: B6C3F1
    • Dose: +, 0, 100, 250, 500, 1000 MG/KG/DAY.
  • 180 days Immunotoxicity (Gavage)  (IMM96004)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 100, 250, OR 500 MG/KG TWICE DAILY.
  • Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT92126)  Completed 
    • Male and Female Mice: CD-1
    • Dose: N/A; 0, 500, 1000, 2000 MG/KG; N/A; N/A.
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