Testing Status of Ozone/NNK M890006

 

CASRN: OZONNNKCOMB

Formula: O3/C10-H13-N3-O2

Synonyms/Common Names

  • 1-BUTANONE, 4-(METHYLNITROSOAMINO)-1-3-PYRIDINYL)- (9CI)
  • NNK

Secondary:

  • 64091-91-4 - 4-(N-Nitroso-N-methylamino)-1-(3-pyridyl)-1-butanone
  • 10028-15-6 - Ozone
  • 10028-15-6 - Ozone (Airways Disease Project)

Known Uses

Byproduct of tobacco smoke. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C88034C)  Report Complete 
    • TR-440 (NIH Number: 95-3371)  (Peer Review Approval 11/16/1993A )
      Toxicology and Carcinogenesis Studies of Ozone (CASRN 10028-15-6) and Ozone/NNK (CASRN 10028-15-6/64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N
    • Dose: MALE RATS ONLY: 0, 0.5 PPM OZONE WITH 0, 0.1, 1.0 MG/KG NNK BY S.C. INJECTION (20 WEEKS ONLY).