Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Ozone/NNK M890006

 

CASRN: OZONNNKCOMB

Formula: O3/C10-H13-N3-O2

Synonyms/Common Names

  • 1-BUTANONE, 4-(METHYLNITROSOAMINO)-1-3-PYRIDINYL)- (9CI)
  • NNK

Secondary:

  • 64091-91-4 - 4-(N-Nitroso-N-methylamino)-1-(3-pyridyl)-1-butanone
  • 10028-15-6 - Ozone
  • 10028-15-6 - Ozone (Airways Disease Project)

Known Uses

Byproduct of tobacco smoke. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C88034C)  Completed 
    • TR-440 (NIH Number: 95-3371)  (Peer Review Approval 11/16/1993A )
      Toxicology and Carcinogenesis Studies of Ozone (CASRN 10028-15-6) and Ozone/NNK (CASRN 10028-15-6/64091-91-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N
    • Dose: MALE RATS ONLY: 0, 0.5 PPM OZONE WITH 0, 0.1, 1.0 MG/KG NNK BY S.C. INJECTION (20 WEEKS ONLY).