National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m890009

Testing Status of Interferon AD (AIDS Initiative) - M890009

 

CASRN: INTERFERONAD

Related: INTERFERON A

Formula: N/F

Known Uses

Experimental AIDS therapy

Short-Term Toxicity

  • 4 weeks (Subcutaneous Injection)  (C89003)  Completed 
    • Mice: B6C3F1
    • Dose: 500, 5000, 50000, OR 500000 UNITS DAY.

Long-Term Carcinogenicity

  • 2 years (Subcutaneous Injection)  (C89003)  Report Complete 
    • TR-469 (NIH Number: 99-3959)  (Peer Review Approval 12/11/1996A )
      Toxicology and Carcinogenesis Studies of AZT (CASRN 30516-87-1) and AZT/ a-Interferon A/D B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Dose: MICE ONLY: 500 OR 5000 UNITS 3X/WEEK; 50/SEX/GROUP.
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