Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Interferon AD + 3'-azido-3'-deoxythymidine (AIDS Initiative) M890012

 

CASRN: INTAZTCOMB

Formula: N/F

Secondary:

  • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
  • 30516-87-1 - AZT transplacental carcinogenesis study
  • INTERFERONAD - Interferon AD (AIDS Initiative)

Known Uses

Used in the experimental treatment of AIDS

Short-Term Toxicity

  • 4 weeks (Subcutaneous Injection and Gavage)  (C89006)  Completed 
    • Mice: B6C3F1
    • Dose: DUAL ROUTES: IFN-AD (SC/IJ): 500, 5000, 50000, OR 500000 UNITS/MOUSE/DAY AZT (GAVAGE): 0, 500, OR 1000 MG/KG.

Long-Term Carcinogenicity

  • 2 years (Subcutaneous Injection and Gavage)  (C89006)  Completed 
    • TR-469 (NIH Number: 99-3959)  (Peer Review Approval 12/11/1996A )
      Toxicology and Carcinogenesis Studies of AZT (CASRN 30516-87-1) and AZT/ a-Interferon A/D B6C3F1 Mice (Gavage Studies)
    • Mice: B6C3F1
    • Dose: DUAL ROUTES WITH BOTH COMPOUNDS: AZT: 0, 30, 60, OR 120 (GAV) MG/KG; IFN: 500 OR 5000 UNITS 3X/WEEK.