National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m890015

Testing Status of Pesticide/fertilizer contamination--mixture 2 - M890015

 

CASRN: PESTFERTMIX2

Formula: N/F

Synonyms/Common Names

  • California mixture

Secondary:

  • 116-06-3 - Aldicarb
  • 1646-87-3 - Aldicarb sulfoxide
  • 1646-88-4 - Aldicarb sulfone
  • 6484-52-2 - Ammonium nitrate
  • 1912-24-9 - Atrazine
  • 96-12-8 - 1,2-Dibromo-3-chloropropane
  • 106-93-4 - 1,2-Dibromoethane
  • 78-87-5 - 1,2-Dichloropropane (propylene dichloride)
  • 122-34-9 - Simazine

Known Uses

Groundwater contamination by pesticides and fertilizers. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Short-Term Toxicity

  • 26 weeks (Dosed-Water)  (C89009)  Report Complete 
    • TOX-36 (NIH Number: 93-3385)
      Toxicity Studies of Pesticide/Fertilizer Mixtures Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: RATS AND MICE (0, 0.1X, 1X, 10X, OR 100X); RATS 40/GROUP; MICE 30/GROUP.

Genetic Toxicology

  • Micronucleus  (A53723)  Completed 
    • Mice: MICE
    • Female Negative (Nonstandard Protocol) 

Organ Systems Toxicity

  • greater than 120 days Continuous Breeding (Legacy) (Dosed-Water)  (RACB90027)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Pesticide/Fertilizer Mixture II in CD-1 Swiss Mice
    • Male and Female Mice: Swiss
    • Dose: N/A; 0,1,10,100 X; N/A; 0,100X.
  • 6 to 20 GD Conventional Teratology (Dosed-Water)  (TER90031)  Completed 
    • Citation: Final Report on the Developmental Toxicity of California Pesticide/Fertilizer Mixture in Sprague-Dawley (CD) Rats
    • Rats: Sprague Dawley
    • Rats Maternal Negative 
    • Rats Fetal Negative 
    • Dose: 0X, 1X, 10X, 100X.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.