National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m890016

Testing Status of Pesticide/fertilizer contamination--mixture 3 - M890016

 

CASRN: PESTFERTMIX3

Formula: N/F

Synonyms/Common Names

  • Iowa mixture

Secondary:

  • 15972-60-8 - Alachlor
  • 6484-52-2 - Ammonium nitrate
  • 1912-24-9 - Atrazine
  • 21725-46-2 - Cyanazine
  • 51218-45-2 - Metolachlor
  • 21087-64-9 - Metribuzin

Known Uses

Groundwater contamination by pesticides and fertilizers. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Short-Term Toxicity

  • 26 weeks (Dosed-Water)  (C89010)  Report Complete 
    • TOX-36 (NIH Number: 93-3385)
      Toxicity Studies of Pesticide/Fertilizer Mixtures Administered in Drinking Water to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: RATS AND MICE (0, 0.1X, 1X, 10X, OR 100X); RATS 40/GROUP, MICE 30/GROUP.

Genetic Toxicology

  • Micronucleus  (A48542)  Completed 
    • Mice: MICE
    • Female Positive (Nonstandard Protocol) 

Organ Systems Toxicity

  • Continuous Breeding (Legacy) (Dosed-Water)  (RACB90029)  Completed 
    • Citation: Final Report on the Reproductive Toxicity of Iowa Pesticide/Fertilizer Mixture (IWA) in CD-1 Swiss Mice
    • Citation: Heindel JJ, Chapin RE, Gulati DK, George JD, Price CJ, Marr MC, Myers CB, Barnes LH, Fail PA, Grizzle TB, Schwetz BA, and Yang RSH. Assessment of the Reproductive and Developmental Toxicity of Pesticide/Fertilizer Mixtures Based on Confirmed Pesticide Contamination in California and Iowa Groundwater. Fund. Appl. Toxicol. 22:605-621 (1994).
    • Male and Female Mice: Swiss
    • Dose: N/A; 0, 1, 10, 100 X; N/A; 0, 100 X.
  • 6 to 20 GD Conventional Teratology (Dosed-Water)  (TER91032)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Iowa Pesticide/Fertilizer Mixture (IWA) in Sprague-Dawley Rats and Supplement
    • Citation: Heindel JJ, Chapin RE, Gulati DK, George JD, Price CJ, Marr MC, Myers CB, Barnes LH, Fail PA, Grizzle TB, Schwetz BA, and Yang RSH. Assessment of the Reproductive and Developmental Toxicity of Pesticide/Fertilizer Mixtures Based on Confirmed Pesticide Contamination in California and Iowa Groundwater. Fund. Appl. Toxicol. 22:605-621 (1994).
    • Rats: Sprague Dawley
    • Rats Maternal Negative 
    • Rats Fetal Negative 
    • Dose: 0X, 1X, 10X, AND 100X.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.