Testing Status of 6-Thioguanine (6-TG) M890081

 

CASRN: 154-42-7

Formula: C5-H5-N5-S

Synonyms/Common Names

  • 6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI)

Known Uses

Medication: antineoplastic agent & immunosuppressive agent.

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (A59828)  Completed 
    • Chromosome Aberrations Positive 
  • Micronucleus  (414883)  Completed 
    • Citation: Phillips, M.D., Nascimbeni, B., Tice, R.R., and Shelby, M.D. Induction of MN in Mouse BM cells: An evaluation of nucleoside analogues used in the treatment of Aids. Environ. Molec. Mutag. Vol. 18 (1991) 168-183
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (024759)  Completed 
    •  Positive 
  • Salmonella  (A64894)  Completed 
    •  Negative