National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m890085

Testing Status of 2',3'-Dideoxyadenosine - M890085

 

CASRN: 4097-22-7

Formula: C10-H13-N5-O2

Synonyms/Common Names

  • beta-D-erythro-Pentofuranoside, adenine-9 2,3-dideoxy-

Known Uses

Used in treatment of AIDS

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (572048)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Positive 
  • Micronucleus  (918660)  Completed 
    • Citation: Phillips, M.D., Nascimbeni, B., Tice, R.R., and Shelby, M.D. Induction of MN in Mouse BM cells: An evaluation of nucleoside analogues used in the treatment of Aids. Environ. Molec. Mutag. Vol. 18 (1991) 168-183
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (074637)  Completed 
    •  Weakly Positive 
  • Salmonella  (A45663)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 42 weeks Immunotoxicity (Gavage)  (IMM89060)  Completed 
    • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Immunological Evaluation of Dideoxyadenosine Effect on LP-BM5 (MAIDS) Infection in Female C57Bl/6 Mice
    • Female Mice: C57BL/6
    • Dose: 0, 50, 100, OR 200 DDA; 0, 50, 100, OR 200 DDA + MAIDS.
  • 30 days Immunotoxicity (Gavage)  (IMM90014)  Completed 
    • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Immunotoxicity of Dideoxyadenosine In Female C57Bl/6 Mice
    • Female Mice: C57BL/6
    • Mice Female Positive 
    • Dose: 0, 87.5, 175, OR 350 MG/KG AND METHOTREXATE (MTX) 3 MG/KG ADMINISTERED INTRAPERITONEALLY.
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