National Toxicology Program

National Toxicology Program

Testing Status of Ribavirin - M890086


CASRN: 36791-04-5

Formula: C8-H12-N4-O5

Synonyms/Common Names

  • 1H-1,2,4-Triazole-3-carboxamide, 1-beta-D-ribofuranosyl-(9CI)

Known Uses

Synthetic, non-interferon-inducing broad spectrum antiviral nucleoside (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (048858)  Completed 
    • Sister Chromatid Exchange Positive 
    • Chromosome Aberrations Negative 
  • Micronucleus  (949294)  Completed 
    • Citation: Phillips, M.D., Nascimbeni, B., Tice, R.R., and Shelby, M.D. Induction of MN in Mouse BM cells: An evaluation of nucleoside analogues used in the treatment of Aids. Environ. Molec. Mutag. Vol. 18 (1991) 168-183
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (240437)  Completed 
    •  Negative 
  • Salmonella  (A06370)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Gavage)  (IMM90010)  Completed 
    • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Immunotoxicity of Ribavirin in Female C57Bl/6 Mice
    • Female Mice: C57BL/6
    • Mice Female Positive 
    • Dose: 0, 75, 150, 300 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.