National Toxicology Program

National Toxicology Program

Testing Status of 1,2,3,4-Butanetetracarboxylic acid - M90009


CASRN: 1703-58-8

Formula: C8-H10-O8

Synonyms/Common Names

  • 1,1,4,4-Btca
  • Butanetetracarboxylic acid
  • Mesobutane-1,2,3,4-Tetracarboxylic Acid
  • Tetracarboxybutane

Known Uses

Substitute for formaldehyde; curing agent in expoxy resin systems; as a component of alkyd resins used in plastics, paint vehicles, and decorative coatings; as a starting material used with polyamines to produce water soluble polyimide resins for electric wirecoatings, films, composite matrices, adhesives and ultrafiltration membranes (Fung 2/3/92).

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Genetic Toxicology

  • Salmonella  (782581)  Completed 
    •  Positive 

Organ Systems Toxicity

  • Continuous Breeding (Dosed-Water)  (RACB92142)  Completed 
    • Male and Female Rats: Sprague Dawley
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER97004)  Completed 
    • Citation: Developmental Toxicity Evaluation of 1,2,3,4-Butanetetracarboxylic Acid(CASRN 1703-58-8)) Administered by Gavage toSprague-Dawley (CD) Rats from Gestational Day 6 through 19
    • Female Rats: Sprague Dawley
    • Dose: 0, 250, 500, OR 1000 MG/KG/DAY.
  • Teratology Pilot Studies (Gavage)  (TRP92056)  Completed 
    • Rats
  • Teratology Pilot Studies (Gavage)  (TRP92057)  Completed 
    • Rabbit: New Zealand White
  • nonpregnant pilot animals dosed on 1 to 14 days and pregnant screen animals dosed on 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP97004)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 50, 100, 500, 750 OR 1000 MG/KG/DAY (NONPREGNANT PILOT); 0, 62.5, 125, 250, 500 OR 1000 MG/KG/DAY (PREGNANT SCREEN).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.