Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of 1,2,3,4-Butanetetracarboxylic acid M90009


CASRN: 1703-58-8

Formula: C8-H10-O8

Synonyms/Common Names

  • 1,1,4,4-Btca
  • Butanetetracarboxylic acid
  • Mesobutane-1,2,3,4-Tetracarboxylic Acid
  • Tetracarboxybutane

Known Uses

Substitute for formaldehyde; curing agent in expoxy resin systems; as a component of alkyd resins used in plastics, paint vehicles, and decorative coatings; as a starting material used with polyamines to produce water soluble polyimide resins for electric wirecoatings, films, composite matrices, adhesives and ultrafiltration membranes (Fung 2/3/92).

Chemical Properties

Toxicity Effects (HSDB)

Genetic Toxicology

  • Salmonella  (782581)  Completed 
    •  Positive 

Organ Systems Toxicity

  • Continuous Breeding (Dosed-Water)  (RACB92142)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: N/A; N/A; N/A; N/A.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER97004)  Completed 
    • Citation: Developmental Toxicity Evaluation of 1,2,3,4-Butanetetracarboxylic Acid(CASRN 1703-58-8)) Administered by Gavage toSprague-Dawley (CD) Rats from Gestational Day 6 through 19
    • Female Rats: Sprague Dawley
    • Dose: 0, 250, 500, OR 1000 MG/KG/DAY.
  • Teratology Pilot Studies (Gavage)  (TRP92056)  Completed 
    • Rats
    • Dose: 0, 50, 200, 400, 600, 800 MG/KG/DAY.
  • Teratology Pilot Studies (Gavage)  (TRP92057)  Completed 
    • Rabbit: New Zealand White
    • Dose: 0, 50, 150, 300, 450, 600 MG/KG/DAY.
  • nonpregnant pilot animals dosed on 1 to 14 days and pregnant screen animals dosed on 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP97004)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 50, 100, 500, 750 OR 1000 MG/KG/DAY (NONPREGNANT PILOT); 0, 62.5, 125, 250, 500 OR 1000 MG/KG/DAY (PREGNANT SCREEN).