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Testing Status of Chlorpyrifos (Dursban) M90011

 

CASRN: 2921-88-2

Formula: C9-H11-Cl3-N-O3-P-S

Synonyms/Common Names

  • Brodan
  • Dowco 179
  • Dursban
  • ENT 27311
  • Killmaster
  • Lorsban
  • Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester
  • Pyrinex
  • Spannit
  • Suscon
  • Trichlorpyrphos

Known Uses

Pesticide; acaricide; drug; agricultural chemical. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0321)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: CHLORPYRIFOS IV RATS & MICE 3 MG/KG BW, GAV RATS & MICE 3, 9 & 30 MG/KG BW; 3, 5, 6-TRICHLORO-1, 2-PYRIDINOL IV RATS & MICE 1.66 MG/KG BW.
  • C. elegans  (S0864)  Completed 
    • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
    • C. elegans
    • Dose: feed (.42, .53, .67, .87, 1.07, 1.33, 1.67, 2.13, 2.67, 3.33, 4.20) 06/14/06 repro (0.01, 0.016, 0.025, 0.04, 0.063, 0.1, 0.16, 0.25, 0.4, 0.63, 1.0 )mM 10/25/04 growth (3.2, 4.0, 5.0, 6.3, 7.9, 10, 12.6, 16, 20, 25, 32) 04/25/06.

Genetic Toxicology

  • Salmonella  (A83234)  Completed 
    •  Negative 

Organ Systems Toxicity

  • in-life phase conducted between Februrary 1, 1993 and March 10, 1993 Immunotoxicity (Topical Application)  (IMM95001)  Completed 
    • Female Mice: B6C3F1
    • Mice Female  NOT A SENSITIZER
    • NOT A SENSITIZER
    • Dose: 0.3, 1.0 & 3.0% IN ACETONE (99.8%) FOR SENSITIZATION, & 3.0% FOR CHALLENGE IN COMBINED MEST & LLNA & 1.0% & 3.0% IN THE LLNA ALONE. DNFB WAS USED AS THE POSITIVE CONTROL AT A CONCENTRATION OF 0.25% FOR SENSITIZATION & 0.5% FOR CHALLENGE..
  • 14 GD - PND42 Juvenile Pesticide Assessment (Gavage)  (JPA96001)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, 2.5, 3.0, OR 5.0 MG/KG/DAY.