National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m90011

Testing Status of Chlorpyrifos (Dursban) - M90011

 

CASRN: 2921-88-2

Formula: C9-H11-Cl3-N-O3-P-S

Synonyms/Common Names

  • Brodan
  • Dowco 179
  • Dursban
  • ENT 27311
  • Killmaster
  • Lorsban
  • Phosphorothioic acid, O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester
  • Pyrinex
  • Spannit
  • Suscon
  • Trichlorpyrphos

Known Uses

Pesticide; acaricide; drug; agricultural chemical. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (S0321)  Completed 
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: CHLORPYRIFOS IV RATS & MICE 3 MG/KG BW, GAV RATS & MICE 3, 9 & 30 MG/KG BW; 3, 5, 6-TRICHLORO-1, 2-PYRIDINOL IV RATS & MICE 1.66 MG/KG BW.
  • C. elegans  (S0864)  Completed 
    • C. elegans
    • Dose: feed (.42, .53, .67, .87, 1.07, 1.33, 1.67, 2.13, 2.67, 3.33, 4.20) 06/14/06 repro (0.01, 0.016, 0.025, 0.04, 0.063, 0.1, 0.16, 0.25, 0.4, 0.63, 1.0 )mM 10/25/04 growth (3.2, 4.0, 5.0, 6.3, 7.9, 10, 12.6, 16, 20, 25, 32) 04/25/06.

Genetic Toxicology

  • Salmonella  (A83234)  Completed 
    •  Negative 

Organ Systems Toxicity

  • in-life phase conducted between Februrary 1, 1993 and March 10, 1993 Immunotoxicity (Topical Application)  (IMM95001)  Completed 
    • Female Mice: B6C3F1
    • Mice Female  NOT A SENSITIZER
    • NOT A SENSITIZER
    • Dose: 0.3, 1.0 & 3.0% IN ACETONE (99.8%) FOR SENSITIZATION, & 3.0% FOR CHALLENGE IN COMBINED MEST & LLNA & 1.0% & 3.0% IN THE LLNA ALONE. DNFB WAS USED AS THE POSITIVE CONTROL AT A CONCENTRATION OF 0.25% FOR SENSITIZATION & 0.5% FOR CHALLENGE..
  • 14 GD - PND42 Juvenile Pesticide Assessment (Gavage)  (JPA96001)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, 2.5, 3.0, OR 5.0 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.