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Testing Status of Propylene glycol mono-t-butyl ether M90029

 

CASRN: 57018-52-7

Formula: C7-H16-O2

Synonyms/Common Names

  • 1-(1,1-Dimethylethoxy)-2-propanol (9CI)
  • PGMBE
  • PGTBE
  • Propylene glycol t-butyl ether
  • tert-Butoxypropanol

Known Uses

Solvent (used as a substitute solvent for ethylene glycol mono alkyl ethers); used in all purpose cleaners, coatings, inks, nail polish, lacquers, latex paints and adhesives.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C90004)  Completed 
    • Rats: F344/N; Rats: NCI Black Reiter (NBR); Mice: B6C3F1
    • Dose: R&M: 0, 75, 150, 300, 600, OR 1200 PPM; 5/SEX/SPECIES/GROUP.
  • 13 weeks (Inhalation)  (C90004)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 75, 150, 300, 600, OR 1200 PPM; 20/SEX/GROUP M: 0, 75, 150, 300, 600, OR 1200 PPM; 10/SEX/GROUP.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C90004)  Completed 
    • TR-515 (NIH Number: 04-4449)  (Peer Review Approval 05/22/2003A )
      Toxicology and Carcinogenesis Studies of Propylene Glycol Mono-t-Butyl Ether (CASRN 57018-52-7) in F344/N Rats and B6C3F1 Mice and a Toxicology Study of Propylene Glycol Mono-t-Butyl Ether In Male NBR Rats (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 75, 300, OR 1200 PPM; 50/SEX/SPECIES/GROUP.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0179)  Completed 
    • Male Rats: F344/N
    • Dose: 377.1, 37.71, 3.77 MG/KG.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (911469)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Negative 
  • Micronucleus  (A04540)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Weakly Positive 
  • Salmonella  (A40505)  Completed 
    •  Positive