National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m910039

Testing Status of Nocodazole - M910039

 

CASRN: 31430-18-9

Formula: C14-H11-N3-O3-S

Synonyms/Common Names

  • 2-Benzimidazolecarbamic acid, 5-(2-thenoyl)-, methyl ester

Known Uses

Antihelmintic, antineoplastic, synthetic microtubule inhibitor

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • Dominant Lethal (Female)  (DLF058)  Completed 
    • Citation: Generoso, W.M, Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Mitchell, T.J., and Bishop, J.B. Chromosome malsegregation and embryonic lethality induced by treatment of normally ovulated mouse oocytes with nocodazole. Mutation Res. 210:313-322 (1989).
    • Female Mice: C3H X C57BL
    • Mice Female Negative 
  • Dominant Lethal (Female)  (DLF059)  Completed 
    • Citation: Generoso, W.M, Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Mitchell, T.J., and Bishop, J.B. Chromosome malsegregation and embryonic lethality induced by treatment of normally ovulated mouse oocytes with nocodazole. Mutation Res. 210:313-322 (1989).
    • Female Mice: SEC X C57BL
    • Mice Female Negative 
  • Preimplantation Zygote Effects  (PZEF54)  Completed 
    • Citation: Generoso, W.M, Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Mitchell, T.J., and Bishop, J.B. Chromosome malsegregation and embryonic lethality induced by treatment of normally ovulated mouse oocytes with nocodazole. Mutation Res. 210:313-322 (1989).
    • Female Mice: SEC X C57BL
    • Mice Female Positive 
  • Preimplantation Zygote Effects  (PZEF55)  Completed 
    • Citation: Generoso, W.M, Katoh, M., Cain, K.T., Hughes, L.A., Foxworth, L.B., Mitchell, T.J., and Bishop, J.B. Chromosome malsegregation and embryonic lethality induced by treatment of normally ovulated mouse oocytes with nocodazole. Mutation Res. 210:313-322 (1989).
    • Female Mice: C3H X C57BL
    • Mice Female Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.