National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m910041

Testing Status of 4-(N-Nitroso-N-methylamino)-1-(3-pyridyl)-1-butanone - M910041

 

CASRN: 64091-91-4

Related: OZONE/NNK COMBINATION (OZONNKCOMB)

Formula: C10-H13-N3-O2

Synonyms/Common Names

  • 1-Butanone, 4-(methylnitrosoamino)-1-(3-pyridinyl)-
  • NNK

Known Uses

Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Other (in-vitro)  (S0124)  Completed 
    • Citation: Zhu SY, Cunningham ML, Gray TE, Nettesheim P. Cytotoxicity, genotoxicity and transforming activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rat tracheal epithelial cells. Mutat Res. 1991 Dec;261(4):249-59.Pubmed Abstract
    • Male Rats: F344/N
  • Other  (S0480)  Completed 
    • Citation: Zhu SY, Cunningham ML, Gray TE, Nettesheim P. Cytotoxicity, genotoxicity and transforming activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rat tracheal epithelial cells. Mutat Res. 1991 Dec;261(4):249-59.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • Micronucleus  (294088)  Completed 
    • Mice: B6C3F1
    • Male Negative 
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