Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Scopolamine hydrobromide trihydrate M910058

 

CASRN: 6533-68-2

Formula: C17-H21-N-O4.Br-H.3H2-O

Synonyms/Common Names

  • Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(sup 2,4))non-7-yl ester, hydrobromide, trihydrate, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-
  • Hyoscine hydrobromide

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Gavage)  (C03098A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 14-Day (Dosed-Water)  (C03098B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Gavage)  (C03098A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 15, 1200 MG/KG/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 & 3 years (Gavage)  (C03098C)  Completed 
    • TR-445 (NIH Number: 97-3361)  (Peer Review Approval 06/20/1995A )
      Toxicology and Carcinogenesis Studies of Scopolamine Hydrobromide Trihydrate (CASRN 6533-68-2) in F344 Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
      •  Mice No Evidence 
    • Dose: R&M: 0, 1, 5, OR 25 MG/KG; 70/GROUP DIET RESTRICTION MICE: 0 OR 25 MG/KG; 70/GROUP.

Genetic Toxicology

  • In Vitro Cytogenetics (CA/SCE)  (243331)  Completed 
    • Sister Chromatid Exchange Negative 
    • Chromosome Aberrations Weakly Positive 
  • Salmonella  (907250)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative