National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m910069

Testing Status of Wyeth 14,643 (WY) - M910069

 

CASRN: 50892-23-4

Related: PEROXISOME PROJECT (WY-14643)

Formula: C14-H14-Cl-N3-O2-S

Synonyms/Common Names

  • (4-Chloro-6-(2,3-dimethylphenyl)amino)-2-pyrimidinyl-1)thio)- acetic acid (9CI)
  • (4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthio) acetic acid (WY-14643)
  • Pirinixic acid
  • WY-14643
  • Wyeth 14,643

Known Uses

Developed by the pharmaceutical industry to lower serum cholesterol in humans; not currently used clinically

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 days (Gavage)  (C91069B)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 20 mg/kg/day.
  • 28 days (Gavage)  (C91069)  Histopath in progress 
    • Rats: Harlan Sprague-Dawley
    • Dose: M&F: 0, 6.25, 12.5, or 25 mg/kg.

Modified One-Generation

  • Dose Range Finding (Gavage)  (MOG91069)  Completed 
    • Dose Range Finding
    • Rats: Harlan Sprague-Dawley; Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: R: 0, 10, 30, or 100 mg/kg/day.

Special Studies

  • Cell Proliferation (Dosed-Feed)  (S0194)  Completed 
    • Male Rats: F344/N
    • Dose: 50 PPM.
  • Cell Proliferation (Dosed-Feed)  (S0552)  Completed 
    • Citation: Cunningham ML, Pippin LL, Anderson NL, Wenk ML. The hepatocarcinogen methapyrilene but not the analog pyrilamine induces sustained hepatocellular replication and protein alterations in F344 rats in a 13-week feed study. Toxicol Appl Pharmacol. 1995 Apr;131(2):216-23.Pubmed Abstract
    • Male Rats
  • Toxicokinetic Study (Dosed-Feed)  (S0583)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
    • Dose: 14D: HAMSTERS 10, 100, 500, 1000 OR 5000 PPM; MICE 10, 50, 100, 500 OR 1000 PPM; 90D: RATS, MICE & HAMSTERS 5, 10, 50, 100 OR 500 PPM.
  • Toxicokinetic Study (Dosed-Feed; Gavage; Intravenous)  (S0629)  Completed 
    • Male Rats: Wistar; Male Mice: B6C3F1; Male Hamsters: Syrian Golden; Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden; Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
    • Dose: Mice: Feed: 50 & 500ppm; iv:2mg/kg; gav:2, 4, 8 mg/kg Rats: Feed: 50 & 500ppm; iv: 2mg/kg; gav: 1, 2, 5 mg/kg Hamsters: Feed: 100 & 1000ppm; iv: 3mg/kg; gav: 1, 3, 10 mg/kg.

Genetic Toxicology

  • Micronucleus  (A06279)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A71798)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G91069)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.