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Testing Status of Perfluorooctanoic acid (PFOA) M910070

 

CASRN: 335-67-1

Formula: C8-H-F15-O2

Synonyms/Common Names

  • C8 Carboxylic acid
  • Pentadecafluorooctanoic acid (9CI)
  • PFOA

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 28 days (Gavage)  (C91070B)  Report in Preparation 
    • Rats: Harlan Sprague-Dawley
    • Dose: Males: 0, 0.625, 1.25, 2.5, 5, or 10 mg/kg; Females: 0, 6.25, 12.5, 25, 50, or 100 mg/kg.
  • 5 days (Gavage)  (C91070C)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 0.156, 0.3125, 0.625, 1.25, 2.5, 5, 10, or 20 mg/kg; N=4.
  • 4 days (Gavage)  (C91070)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: Male mice: 0, 15, 180 mg/kg/day.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C20614B)  Report in Preparation 
    • Rats: Harlan Sprague-Dawley
    • Dose: MR: 0, 20, 40, 80, 300/0, 300/20, 300/40, or 300/80 ppm.
  • 2 years (Dosed-Feed)  (C20614)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Dose: FR: 0, 300, or 1000 ppm; MR: 0, 150, or 300; 60/sex.

Modified One-Generation

  • Dose Range Finding (Gavage)  (MOG91070)  Completed 
    • Dose Range Finding
    • Rats: Harlan Sprague-Dawley; Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: R: 0, 6.25, 12.5, 25, or 50 mg/kg.

Special Studies

  • Cell Proliferation (Gavage)  (S0174)  Completed 
    • Citation: Thottassery J, Winberg L, Youssef J, Cunningham M, Badr M. Regulation of perfluorooctanoic acid-induced peroxisomal enzyme activities and hepatocellular growth by adrenal hormones. Hepatology. 1992 Feb;15(2):316-22.Pubmed Abstract
    • Male Rats: Sprague Dawley
    • Dose: 150 MG/KG.
  • Toxicokinetic Study (Gavage; Intravenous)  (K10075)  Completed 
    • Male and Female Rats: Fischer 344

Genetic Toxicology

  • 4 days Comet Assay (Gavage)  (G91070B)  On Test 
    • Rats: Sprague Dawley
  • Micronucleus  (G91070)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Positive 
    • Female Negative 
  • Salmonella  (A98283)  Completed 
    •  Equivocal 

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T91070B)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
  • 4 days Microarray Analysis (Gavage)  (T91070)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: 180 mg/kg; 6 rats.