National Toxicology Program

National Toxicology Program

Testing Status of 4,4'-Diamino-2,2'-stilbenedisulfonic acid, disodium salt - M910074


CASRN: 7336-20-1

Related: 81-11-8

Formula: C14-H14-N2-O6-S2.2Na

Synonyms/Common Names

  • Amsonic acid disodium salt
  • Diaminostilbene disulphonate (DASD)
  • 2,2'-(1,2-Ethenediyl)bis(5-aminobenzenesulfonic acid) disodium salt
  • Flavonic acid
  • p,p'-Diaminostilbene-o,o'-disulfonic acid

Known Uses

Chemical intermediate for dyes and fluorescent brighteners.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 14-Day (Dosed-Feed)  (C60162)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13-Week (Dosed-Feed)  (C60162)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 6250, 100000 PPM/10 PER GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C60162)  Report Complete 
    • TR-412 (NIH Number: 92-3143)  (Peer Review Approval 07/09/1991A )
      Toxicology and Carcinogenesis Studies of 4,4'-Diamino-2,2'-Stilbenedisulfonic Acid Disodium Salt (CASRN 7336-20-1) in F344 Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 12500, 25000, M: 0, 6250, 12500 PPM/60 PER GROUP.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.