National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m910075

Testing Status of Oleic acid diethanolamine condensate - M910075

 

CASRN: 93-83-4

Related: 13961-86-9 (OLEIC ACID DIETHANOLAMINE)

Formula: C22-H43-N-O3

Synonyms/Common Names

  • N,N-di(2-Hydroxyethyl)oleamide
  • 9-Octadecenamide, N,N-bis(2-hydroxyethyl)-, (Z)- (9CI)
  • Oleamide DEA
  • Oleic acid diethanolamide

Known Uses

Surfactant in wax emulsion; to increase shampoo viscosity

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Topical Application)  (C91014)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 25, 50, 100, 200, OR 400 MG/KG; 20/SEX/GROUP M: 0, 50, 100, 200, 400, OR 800 MG/KG; 10/SEX/GROUP.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C91014)  Report Complete 
    • TR-481 (NIH Number: 99-3971)  (Peer Review Approval 12/10/1997A )
      Toxicology and Carcinogenesis Studies of Oleic Acid Diethanolamine Condensate (CASRN 93-83-4) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 50, OR 100 MG/KG; 50/SEX/GROUP M: 0, 15, OR 30 MG/KG; 55/SEX/GROUP.

Genetic Toxicology

  • Mouse Lymphoma  (932123)  Completed 
    • Mice
    •  Negative 
  • Micronucleus  (A72594)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (669959)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (IMM90004)  Completed 
    • Citation: NTP Summary Reports on Immunotoxicology Vol. 1, No. 1-15: Assessment of Contact Hypersensitivity to Oleic Acid Diethanolamine in Female B6C3F1 Mice
    • Female Mice: B6C3F1
    • Mice Female Negative 
    • Dose: 0, 1, 3, 10%.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.