National Toxicology Program

Testing Status of Glyoxal trimeric dihydrate - M910078

CASRN: 4405-13-4

Related: GLYOXAL, 107-22-2

Formula: C6-H10-O8

Synonyms/Common Names

• (1,4)Dioxino(2,3-b)-1,4-dioxin-2,3,6,7-tetrol, hexahydro-

Known Uses

Pure form of glyoxal is used for permanent-press fabrics, leather tanning, paper coating, textile dyeing, embalming fluids; pharmaceuticals, pesticides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

• 6 to 15 GD Conventional Teratology (Gavage)  (TER92116)  Completed 
  • Citation: Final Report on the Developmental Toxicity of Glyoxal Trimeric Dihydrate in Sprague-Dawley (CD) Rats
  • Citation: Final Report on the Developmental Toxicity of Glyoxal Trimeric Dihydrate in Sprague-Dawley (CD) Rats
  • Female Rats: Sprague Dawley
  • Rats Maternal Positive 
  • Rats Fetal Negative 
  • Dose: 0, 50, 150, 300 MG/KG.
• 6 to 19 GD Conventional Teratology (Gavage)  (TER92121)  Completed 
  • Citation: Final Report on the Developmental Toxicity of Glyoxal Trimeric Dihydrate in New Zealand White Rabbits
  • Citation: Final Report on the Developmental Toxicity of Glyoxal Trimeric Dihydrate in New Zealand White Rabbits
  • Rabbit: New Zealand White
  • Rabbits Maternal Positive 
  • Rabbits Fetal Negative 
  • Dose: REP I: 0, 50, 200, 400 REP II: 0, 50 MG/KG/DAY.
• 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP90035)  Completed 
  • Female Rats: Sprague Dawley
  • Dose: 0, 200, 800, 1200, 1600, OR 2000 MG/KG.
• 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP91016)  Completed 
  • Female Rabbit: New Zealand White
  • Dose: 0, 200, 800, 1000, 1200, OR 1500 MG/KG.
• 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP92059)  Completed 
  • Female Rabbit: New Zealand White
  • Dose: 0, 400, OR 600 MG/KG.