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Testing Status of Fumonisin B1 M920002

 

CASRN: 116355-83-0

Formula: C34-H59-N-O15

Synonyms/Common Names

  • 1,2,3-Propanetricarboxylic acid, 1,1'-(1-(12-amino-4,9,11-trihydroxy-2-methyltridecyl)-2-(1-methylpentyl)-1,2-ethanediyl) ester

Known Uses

Mycotoxin produced by certain strains of fusarium moniliforme, a commonly occurring fungi on U.S. agricultural products, especially corn. No known uses

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Dosed-Feed)  (C92002B)  Completed 
    • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Dose: R&M: 100, 175, 250, or 500 ppm.
  • 13 weeks (Dosed-Feed)  (C92002)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 1, 3, 9, 27, or 81 ppm; 15/sex/species/group.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C92002B)  Completed 
    • TR-496 (NIH Number: 01-3955)  (Peer Review Approval 05/21/1999A )
      Toxicology and Carcinogenesis Studies of Fumonisin B1 (CASRN 116355-83-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
    • Rats: F344/N; Mice: B6C3F1/NCTR BR (C57BL/6N x C3H/HEN MTV-)
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 5, 15, 50, 100, or 150 ppm.

Special Studies

  • C. elegans  (S0952)  Completed 
    • C. elegans

Organ Systems Toxicity

  • 3 to 19 GD Conventional Teratology (Gavage)  (TER94002)  Completed 
    • Female Rabbit: New Zealand White
    • Dose: 0.25, 0.50, 1.25, OR 1.75 MG/KG -- DOSE FINDING STUDY.