National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m920005

Testing Status of 2,3,4,7,8-Pentachlorodibenzofuran - M920005

 

CASRN: 57117-31-4

Formula: C12-H3-Cl5-O

Synonyms/Common Names

  • Dibenzofuran, 2,3,4,7,8-pentachloro-

Known Uses

Contaminant. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

  • Absorption Disposition Metabolism Elimination  (S0518)  Completed 
    • Citation: Brewster DW, Elwell MR, Birnbaum LS. Toxicity and disposition of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) in the rhesus monkey (Macaca mulatta). Toxicol Appl Pharmacol. 1988 Apr;93(2):231-46.Pubmed Abstract
    • Monkey: Rhesus
  • Absorption Disposition Metabolism Elimination  (S0519)  Completed 
    • Citation: Brewster DW, Birnbaum LS. Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat. Toxicol Appl Pharmacol. 1987 Sep 15;90(2):243-52.Pubmed Abstract
    • Male Rats: F344/N
  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0764)  Completed 
    • Citation: Brewster DW, Banks YB, Clark AM, Birnbaum LS. Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three polychlorinated dibenzofurans. Toxicol Appl Pharmacol. 1989 Jan;97(1):156-66.Pubmed Abstract
    • Male Rats: F344/N
  • Toxicokinetic Study (Gavage)  (S0623)  Completed 
    • Citation: Single Gavage Administration Toxicokinetic Study of 2,3,4,7,8- Pentachlorodibenzofuran (PeCDF) in Female Harlan Sprague-Dawley Rats. 3-008-TKS-2. September 30, 2003.
    • Female Rats: Sprague Dawley

Organ Systems Toxicity

  • Single dose Immunotoxicity (Gavage)  (I92005)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 3, 9, 15, 30 and 90 ug/kg.
  • Conventional Teratology (Gavage)  (TER86102)  Completed 
    • Mice: C57BL/6
    • Mice Maternal Positive 
    • Mice Fetal Positive 

Toxicogenomics

  • Microarray Analysis Selected (T92005)  
    NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.