National Toxicology Program

National Toxicology Program

Testing Status of Perfluorodecanoic Acid - M920006


CASRN: 335-76-2

Formula: C10-H-F19-O2

Synonyms/Common Names

  • C10 Carboxylic acid
  • Nonafluorodecanoic acid
  • Nonafluror-n-decanoic acid
  • Perfluoro-n-decanoic acid
  • PFDA

Known Uses

Industrial surfactant; used as either oil or water repellant

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 28 days (Gavage)  (C20615)  Histopath in progress 
    • Rats: Harlan Sprague-Dawley
    • Dose: M&F: 0, 0.156, 0.312, 0.625, 1.25, or 2.5 mg/kg.

Special Studies

  • Mechanisms  (S0688)  Completed 
    • Citation: Harris MW, Uriah LC, Birnbaum LS. Acute toxicity of perfluorodecanoic acid in C57BL/6 mice differs from 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol. 1989 Nov;13(4):723-36.Pubmed Abstract
    • Female Mice: C57BL/6
  • Mechanisms  (S0689)  Completed 
    • Citation: Brewster DW, Birnbaum LS. The biochemical toxicity of perfluorodecanoic acid in the mouse is different from that of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1989 Jul;99(3):544-54.Pubmed Abstract
    • Female Mice: C57BL/6
  • Other  (S0775)  Completed 
    • Citation: Harris MW, Birnbaum LS. Developmental toxicity of perfluorodecanoic acid in C57BL/6N mice. Fundam Appl Toxicol. 1989 Apr;12(3):442-8.Pubmed Abstract
    • Mice: C57BL/6

Genetic Toxicology

  • Micronucleus  (G92006)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (A10025)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Gavage)  (I92006)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 0.125, 0.25, 0.5, 1 or 2 mg/kg/day.
  • 6 GD to PND 21 Conventional Teratology (Gavage) Selected (R92006)  
    • Rats: Sprague Dawley
  • Conventional Teratology (Gavage)  (TER89103)  Completed 
    • Mice: C57BL/6
    • Mice Maternal Positive 
    • Mice Fetal Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.